Although teg studies have expanded to many other clinical scenarios. View and download powerpoint presentations on hemostasis ppt. Here is another picture to help with memorizing the coagulation cascade without the. Clotting cascade plays a very important role in healing the injury of the blood vessel and other injury site of the body. Here youll find tools, resources, and detailed information about both common and complex bleeding disorders. Coagulation cascade intrinsic and extrinsic pathway duration. To explain the coagulation factors and the clotting cascade pathway to your audience in a very creative way you can use clotting cascade powerpoint templates. Coagulation cascade coagulation macromolecules free. Coagulation cascade free download as powerpoint presentation.
The recently recognised, but steadily growing, knowledge of the relationship between the coagulation and. Coags uncomplicated is an educational resource for health care providers. Hemostasis is the interaction of platelets, vessels and clotting factors to stop bleeding. It may make a substantial contribution to tumour angiogenesis, which represents an imbalance in the normal mechanisms that allow organised healing after injury. The factors involved in common pathway can be remembered by a mnemonic. The coagulation cascade is the mechanism by which blood clots, and is important to understand. Coagulation cascade an overview sciencedirect topics. Each solid black arrow leads to the result of whatever reaction is catalyzed. Thrombin is the key effector enzyme of the clotting cascade. It outlines the basis of hemostasis and disorders of this cascade can lead to hypercoagulability or conversely, problems with clotting, leading to hemorrhage. It potentially results in hemostasis, the cessation of blood loss from a damaged vessel, followed by repair. The coagulation proteins may be classified into three groups.
Ive borrowed okay, stolen bits of this from other smart people like michael lapetina, and ive lent it to many others. Once you have the core principles in place, it is much easier to build on in terms of all the positive versus negative feedback loops and other circulating proteinsmolecules. Ginsburg, in reference module in biomedical sciences, 2014. Diagram 1 shows the intrinsic and extrinsic pathways of coagulation. See more ideas about hematology, medical laboratory and coagulation cascade. Blood coagulation and thrombophilia johns hopkins medicine. Nice powerpoint template will be great choice for medical presentations on thrombus, blood clot causes, blood coagulation, platelet plug, clotting, thrombosis, etc. Coagulation cascade simplest explanation the extrinsic. How i teach the coagulation cascade ash clinical news. The coagulation cascade is therefore classically divided into three pathways. Although the concept of the coagulation cascade represented a significant advance in the understanding of coagulation and served for many years as a useful model, more recent clinical and experimental observations demonstrate that the cascadewaterfall hypothesis does not fully and completely reflect the events of hemostasis in vivo.
Contact me through youtube for permission to use for other purposes. Excessive activation of the coagulation system by endotoxin leads to lifethreatening disseminated intravascular coagulation dic. The coagulation cascade 1st video presentation a walkthrough of coagulation cascade basics. Each enzyme of the pathway is present in the plasma as a zymogen, in other words in an inactive form, which on activation undergoes proteolytic cleavage to release the active factor from the precursor molecule. When tissues are injured, blood cell fragments called platelets gather at the wound, providing a foundation for coagulation clotting. The coagulation system, which is activated in most cancer patients, has an important role in tumour biology. Pdf the coagulation cascade in sepsis researchgate. In addition, the virally encoded glycoprotein c enhances activation of fx.
It is seen that both the extrinsic and intrinsic pathway goes on to activate factor x and forming prothrombin activator which convert prothrombin to thrombin which subsequently catalyzes the conversion of fibrinogen to fibrin fibers. Coagulation cascade pathway, intrinsic pathway, extrinsic pathway created date. The clotting cascade is definitely much more complex than what has been simplified for the purposes of this post, and it is very interesting how the human body works. This presentation gives a brief information about the coagulation cascade both extrinsic as well as intrinsic pathway of blood clotting.
The clotting system consists of a series of proteolytic reactions, in each of which an inactive precursor zymogen of a proteolytic enzyme is converted to the active enzyme. Platelets also contribute to secondary hemostasis coagulation cascade by providing a phospholipid. The mechanism of coagulation involves activation, adhesion and aggregation of platelets, as well as deposition and maturation of fibrin. The coagulation cascade with its intrinsic and extrinsic pathways is a widely accepted paradigm for coagulation. Pink arrows show what is being destroyed in the reaction. Bacterial endotoxin activates the coagulation cascade. Investigations over many years identified an ordered cascade consisting of a plasma protease. Scribd is the worlds largest social reading and publishing site. Affordable and search from millions of royalty free images, photos and vectors. The fibrinogen family of proteins includes fibrinogen, factor v, factor viii, and factor xiii. Exposes tissue factor for activating coagulation collagen collagen. Its application is currently limited to liver transplantation and cardiopulmonary bypass surgery where tegbased algorithms have been shown to reduce blood product use.
Coagulation is a major haemostatic function responsible for prevention and termination of bleeding following injury. Hemostatic disorders can be either platelet or coagulation cascade problems. The role of the coagulation system in tumour angiogenesis. The coagulation cascade pdfs to download feel free to browse and download these pdfs for personal use. Coagulation cascade is activated by 2 pathways, the extrinsic and intrinsic which culminates into a common pathway. The blood coagulation mechanism the blood clothing system or coagulation pathway, like the complement system, is a proteolytic cascade. Ppt hemostasis coagulation powerpoint presentation. Coagulation cascade detailedtraditional view coagulation cascade overview regulation of fibrinolysis thrombin crystal structure tissue factor and coagulation hemostatic controls mechanism of action of heparins and fondaparinux protein c and s function formation of no by nos fibrin polymerization thrombin generation pathways.
Coagulation is a cascade of serine proteasedriven reactions where thrombin is responsible for conversion of fibrinogen to fibrin, and plays a role as a defense mechanism against bacterial pathogens through immobilization of bacteria in a clot and their subsequent killing 14. This shuts down the intrinsic pathway, as well as the extrinsic pathway. See more ideas about coagulation cascade, hematology and medical laboratory science. Find powerpoint presentations and slides using the power of, find free presentations research about hemostasis ppt.
The aggregation leads to the formation of the primary platelet plug and later stabilized by the formation of fibrin. Bleeding disorders coagulation disorders jama jama. The coagulation cascade was historically one of the first biologic systems associated with human disease to be studied in detail at the biochemical level. In september, 2004, a 76yearold man had surgery for traumatic left hip fracture. Once the initial platelet plug is built, clotting factors gather at the injury site to seal the wound, stop bleeding, and begin the healing process. Start to narrow possible disorders by inputting pt and aptt lab results. Find powerpoint presentations and slides using the power of, find free presentations research about coagulation cascade ppt. Simple coagulation cascade with mnemonics epomedicine.
Learn for free about math, art, computer programming, economics, physics, chemistry, biology, medicine, finance, history, and more. The blood coagulation mechanism medical lecture notes. Khan academy is a nonprofit with the mission of providing a free, worldclass education for anyone, anywhere. The biochemistry of blood coagulation has been well defined over. View and download powerpoint presentations on coagulation cascade ppt. Secondary hemostasis activation of coagulation factors and generation of thrombin. Enter the coagulation made easy presentation click to download complete with mnemonics, visual aids, and simple diagrams. This is the overall skeleton of the coagulation cascade. Ppt hemostasis powerpoint presentation free to view. Upon binding to a target cell, tf in the envelope activates the coagulation cascade.
Coagulation cascade animation physiology of hemostasis. It covers similar material to the first youtube presentation. Coagulation system is divided into two pathways extrinsic pathway. Antithrombin, freely floating in the blood, is activated by heparin, made in mast cells. Antagonists of vitamin k inhibit a vitaminkdependent posttranslational modification of several coagulation. The coagulation cascade and par1 and par2 enhance hsv infection of endothelial cells. An enzyme cascade in the blood clotting mechanism, and its function as a biological amplifier. Coagulation, also known as clotting, is the process by which blood changes from a liquid to a gel, forming a blood clot.
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